Neuropharmacological effects of TAK-147, a novel acetylcholinesterase inhibitor, in the rat brain in vitro.
نویسندگان
چکیده
منابع مشابه
Central selective acetylcholinesterase inhibitor with neurotrophic activity: structure-activity relationships of TAK-147 and related compounds.
A series of benzylamino inhibitors of acetylcholinesterase (AChE) have been designed based on a working hypothesis of the enzyme s active site. These compounds were tested for their inhibitory activities on AChE and potent inhibitors were further evaluated in terms of central selectivity. These studies led to a discovery of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4, 5-tetrahydro-1H-1-benzazep...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1994
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)51038-1